Environment & Cell State
Environment is a critical aspect of development. At the cellular level, this is demonstrated by changes in gene expression that affect differentiation potential. Our lab uses mouse embryonic stem and human adult stem cells to study the impact that environment has on cell state and differentiation potential.
Transcriptional Machinery & Cell State
Transcriptional machinery is at the core of gene expression.
Proper gene expression is critical for the maintenance of cell state and healthy cellular differentiation during development. Our lab investigates the role of endogenous proteins and signaling cascades on regulating cell state in human adult stem cells.
Image Credit: Tom DiCesare